This protrusion could be uncomfortable, may make exercise difficult, and may hinder sexual functioning. The analysis results appear in the September 17, 2008 Journal of the American Medical Association. 'The analysis results underscore the need to identify the causes of pelvic flooring disorders and the methods to prevent and treat them.' stated Duane Alexander, M.D., director of the NIH's Eunice Kennedy Shriver National Institute of Kid Health and Human Development . 'The NIH Pelvic Flooring Disorders Network is certainly conducting studies to supply essential answers.' Funding was supplied by the NICHD, the National Institute of Diabetes and Digestive and Kidney Illnesses and the Office of Analysis on Women's Health , all at the NIH, and by the National Center for Health Statistics of the Centers for Disease Prevention and Control.It consists of the malfunction and death of essential nerve cells in the mind, called neurons. Some of these dying neurons create dopamine, a chemical substance that sends messages to the area of the brain that controls movement and coordination. As PD progresses, the amount of dopamine created in the brain decreases, departing a person struggling to normally control movement. One million people in the usa have PD currently, and it is approximated that seven to 10 million people around the world suffer from the condition.