Some of the most active molecules developed by Dagan and Gatt are derivatives of ceramide . Ceramide in programmed cell death in a variety of cancer cells male ed drugs . Synthetic moleculesal content of ceramide in cancer cells in the usually too low In preclinical studies a therapeutic effect. In preclinical studies to date various treatments with the synthetic molecules resulted in an elevation of ceramide levels in cancer cells,. Their death by apoptosis Moreover, these synthetic molecules appear to be synergistic with chemotherapeutic drugs.
###Prof. Shimon Gatt and Dr. Arie Dagan is the development of synthetic sphingolipid analogs as anti-cancer drugs through Yissum, the technology transfer company of the Hebrew University of Jerusalem patented. Yissum licensed the technology BioLineRx, since 1994. In the clinical development of drugs on the Tel Aviv. For the development of these synthetic molecules as anti-cancer drugs.
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