Women also must sign a record to acknowledge that isotretinoin can increase risk for birth defects, depression and suicidal thoughts. About 165,000 folks have registered with iPledge, which is administered with companies that sell the drug together. However, critics state that iPledge is poorly administered . Isotretinion is among about two dozen medications prescribed under a 'restricted-access plan intended to curb misuse or needless side effects,' the Journal reviews. According to the IMS Health, a ongoing firm that tracks prescription drug sales, the amount of Accutane prescriptions in the 1st half of 2006 reduced by 46 percent weighed against the same period in 2005, and prescriptions for the leading generic edition fell by 16 percent in once period.The authors wrote the manuscript and made the decision to submit the manuscript for publication. The sponsor of the scholarly study, Ethicon Endo-Surgery European countries , experienced no part in the scholarly study design, data gathering, analyses and interpretation, or composing of the manuscript. Individuals Patients with a solitary adenocarcinoma of the rectum within 15 cm from the anal verge without distant metastases who also were applicants for elective surgery were qualified to receive inclusion. The localization of the tumor was categorized as the top rectum , middle rectum , or lower rectum . Sufferers with T4 tumors or T3 tumors within 2 mm of the endopelvic fascia, as identified on computed tomography or magnetic resonance imaging , were excluded.