With respect to inheritance, we also found a significant bias toward maternal transmission of second-site variants . Independently of this analysis, we found a substantial enrichment of males with variably expressive genomic disorders . Mixed, these results claim that females are less vulnerable to the effects of huge variants than are men. We propose that males, by virtue of carrying a single X chromosome, already are at least partially sensitized due to the inherent exposure to weakly deleterious mutations on the X chromosome.Even if a NEAD chain had been broken due to some complication that precluded a proposed transplantation without getting rid of the bridge donor from the pool, the chain could be extended by finding another recipient still. A second NEAD chain that has generated five transplantations since its initiation in December 2007 was interrupted due to a last-minute positive crossmatch, but an alternative solution recipient was found. It was not until 10 weeks later that the chain was continued, whenever a transplantation from the brand new recipient's bridge donor was performed.