Leukemic CML stem cells may actually remain untouched by both standard tyrosine and chemotherapy kinase inhibitors.17-20 Although sustained complete molecular responses have already been achieved in several instances, the discontinuation of imatinib led to relapse in half of them.21 The cause of relapse is regarded as linked to the persistence of leukemic stem cells. Initial data from the use of second-era tyrosine kinase inhibitors such as dasatinib or nilotinib claim that molecular responses are attained more rapidly with these agents than with imatinib.22,23 The superiority of nilotinib and dasatinib over imatinib with regards to cytogenetic and molecular responses has recently been founded in two stage 3 trials. In addition, the second-generation tyrosine kinase inhibitors usually do not eradicate the stem cells either, resulting in the final outcome that the persistence of leukemic cells is normally a general characteristic of the therapies.However, Dr. Howse said, low-carb and other diets cannot be the only cause of the increase because rates of folic acid make use of were also higher than expected for ladies not really dieting . She also stated the March of Dimes urges all females to consume a varied, nutritious diet before and during pregnancy. Of women who were not pregnant at the time of the 2004 survey, 37 % reported taking a vitamin including folic acid daily, from thirty % in 2003 up. Daily intake of the B vitamin folic acid beginning before pregnancy is essential because serious birth defects of the mind and spine known as neural tube defects occur in the first weeks following conception, before a woman knows she actually is pregnant often.