Risk of Death There was a significant excess risk of death from any cause and from cardiovascular causes among patients with type 1 diabetes who had an up to date mean glycated hemoglobin level of 6. For model 3, and Desk S1 in the Supplementary Appendix for models 1 and 2). In the ultimate model , the hazard ratio for loss of life from any cause among individuals with diabetes was 2.36 in an updated mean glycated hemoglobin degree of 6.9 percent or decrease and risen to 8.51 for a level of 9.. Quantitative analysis of pSer282 and pSer302 levels in accordance with total cMyBP-C detected with the pan Ab in response to PHE and PHE+LY . 7). 7A,B). The trend toward decreased pSer282 in response to PHE also was attenuated when calyculin A was incorporated with PHE . Phosphorylation of cMyBP-C Ser273 was not detected under basal conditions or in response to PHE in any of the 3 myocyte groups . 7A; ref. 16) was not further elevated through the PHE response in the presence or absence of LY . PHE also had little influence on Ser273 and Ser302 phosphorylation in the current presence of calA . Taken together, low dose PHE does not increase phosphorylation levels at specific sites on these myofilament proteins uniformly, although there is evidence PHE accelerates phosphorylation turnover, at least at some sites .